Acute Lesioning and Rapid Repair of Hypothalamic Neurons outside the Blood-Brain Barrier
| Autor: | Eirini Vagena, Alvin Y. Chan, Allison W. Xu, Ernie Yulyaningsih, Christian Vaisse, Arturo Alvarez-Buylla, Ivan A. Rudenko, Martin Valdearcos, Emma Dahlén, Suneil K. Koliwad |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Pro-Opiomelanocortin Monosodium glutamate Hypothalamus Cell lineage Biology Blood–brain barrier General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences chemistry.chemical_compound Mice Proopiomelanocortin Internal medicine Sense (molecular biology) medicine Animals lcsh:QH301-705.5 Neurons digestive oral and skin physiology monosodium glutamate Biological Transport Neural stem cell Cell biology 030104 developmental biology Endocrinology medicine.anatomical_structure lcsh:Biology (General) chemistry nervous system Blood-Brain Barrier repair biology.protein AgRP hormones hormone substitutes and hormone antagonists |
| Zdroj: | Cell Reports, vol 19, iss 11 Cell Reports, Vol 19, Iss 11, Pp 2257-2271 (2017) |
| Popis: | Neurons expressing agouti-related protein (AgRP) are essential for feeding. The majority of these neurons are located outside the blood-brain barrier (BBB), allowing them to directly sense circulating metabolic factors. Here, we show that, in adult mice, AgRP neurons outside the BBB (AgRPOBBB) were rapidly ablated by peripheral administration of monosodium glutamate (MSG), whereas AgRP neurons inside the BBB and most proopiomelanocortin (POMC) neurons were spared. MSG treatment induced proliferation of tanycytes, the putative hypothalamic neural progenitor cells, but the newly proliferated tanycytes did not become neurons. Intriguingly, AgRPOBBB neuronal number increased within a week after MSG treatment, and newly emerging AgRP neurons were derived from post-mitotic cells, including some from the Pomc-expressing cell lineage. Our study reveals that the lack of protection by the BBB renders AgRPOBBB vulnerable to lesioning by circulating toxins but that the rapid re-emergence of AgRPOBBB is part of a reparative process to maintain energy balance. |
| Databáze: | OpenAIRE |
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