Association of FCRL3 C-169T promoter single-nucleotide polymorphism with idiopathic infertility and infertility-related endometriosis
| Autor: | Juliana S. Teles, Bianca Bianco, Fabia Lima Vilarino, Caio Parente Barbosa, Gustavo Mendonça André, Denise Maria Christofolini |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Infertility medicine.medical_specialty Genotype Immunology Idiopathic infertility Endometriosis Single-nucleotide polymorphism medicine.disease_cause Polymorphism Single Nucleotide Gastroenterology Autoimmunity Pathogenesis Gene Frequency Internal medicine Humans Immunology and Allergy Medicine Genetic Predisposition to Disease Receptors Immunologic Promoter Regions Genetic Allele frequency Gynecology business.industry Obstetrics and Gynecology medicine.disease Reproductive Medicine Case-Control Studies Female business Infertility Female |
| Zdroj: | Journal of Reproductive Immunology. 89:212-215 |
| ISSN: | 0165-0378 |
| DOI: | 10.1016/j.jri.2011.02.007 |
| Popis: | An aberrant immunological mechanism is thought to be involved in the pathogenesis of endometriosis. The present study aimed to determine whether there is a relationship between endometriosis and/or infertility and the FCRL3 C-169T polymorphism. This case-control study included 167 infertile women with endometriosis, 60 women with idiopathic infertility and 167 fertile women. Detection of the FCRL3 C-169T polymorphism was performed using TaqMan PCR. A significant difference in the genotype and allele frequencies of the FCRL3 C-169T polymorphism between endometriosis-related infertility ( p =0.003 and p =0.001) and idiopathic infertility ( p =0.027 and p =0.0185) versus controls was demonstrated. In conclusion, the results suggest that the FCRL 3 C-169T polymorphism may play an important role in the pathogenesis of endometriosis and/or infertility. |
| Databáze: | OpenAIRE |
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