| Autor: |
Imam Shah, Farnaz Malik, Muhammad Gulfraz, Shahzad Hussain, Sidra Mahmood, Sadaf Maqsood, Umara Afzal |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
African Journal of Pharmacy and Pharmacology. 7:8-14 |
| ISSN: |
1996-0816 |
| Popis: |
Medicinal plants are believed to be a precious natural reservoir and have been continuously studied for their pharmacological activities against various ailments, liver being no exception. Leaves of Justicia adhatoda L. are being extensively used against many human ailments. Hepatoprotective effects of J. adhatoda L. leaves and flowers were investigated on carbon tetrachloride (CCl4) induced liver damage in Swiss albino mice. Liver injury was assessed by estimation of biochemical parameters which includes liver function tests and supplemented by histopathological examination of liver. Aqueous, ethanolic and methanolic extracts of different concentrations were given orally and activities of these extracts were compared with standard drug (silymarin). The results showed that J. adhatoda leaves and flowers showed unambiguous hepatoprotective activity against CCl4 induced liver toxicity. It was also concluded that different concentrations of leaves and flowers of J. adhatoda did not show any sign and symptoms of toxicity and mortality. Key words: Justicia adhatoda L., Swiss albino mice, silymarin, hepatoprotective effects. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
