Autor: |
Adrian Wai-Hing Cheung, Lisa M. Garofalo, Robert Alan Goodnow, Achyutharao Sidduri |
Rok vydání: |
2000 |
Předmět: |
|
Zdroj: |
Tetrahedron Letters. 41:3303-3307 |
ISSN: |
0040-4039 |
DOI: |
10.1016/s0040-4039(00)00423-8 |
Popis: |
An unexpectedly low N-9/N-7 regioselectivity was obtained when Robins' reagent (2-N-acetyl-6-O-diphenylcarbamoylguanine) was coupled with a d -glucosamine derivative under trimethylsilyl trifluoromethanesulfonate activation. An unprecedented solvent effect (toluene versus dichloroethane) on the N-9/N-7 ratio was also observed in the same study. The use of 2-N-acetyl-6-O-benzylguanine to successfully overcome the above regioselectivity problem is described. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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