Mechanical Rubbing of Blood Clots Using Helical Robots Under Ultrasound Guidance
| Autor: | Anke Klingner, Nabila Hamdi, Ramez Reda Moustafa, Ahmed El Sharkawy, Ahmet Fatih Tabak, Dalia Mahdy, Islam S. M. Khalil, Mohamed E. Mitwally, Metin Sitti, Abdelrahman Mohamed, Sarah Hesham |
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| Rok vydání: | 2018 |
| Předmět: |
Control and Optimization
Materials science Mechanical Engineering Biomedical Engineering 02 engineering and technology Visual feedback 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Computer Science Applications Ultrasonic imaging Rubbing Human-Computer Interaction Shear modulus Ultrasound guidance Artificial Intelligence Control and Systems Engineering Computer Vision and Pattern Recognition Atomic physics 0210 nano-technology Magnetic actuation |
| Zdroj: | IEEE Robotics and Automation Letters. 3:1112-1119 |
| ISSN: | 2377-3774 |
| DOI: | 10.1109/lra.2018.2792156 |
| Popis: | A simple way to mitigate the potential negative side-effects associated with chemical lysis of a blood clot is to tear its fibrin network via mechanical rubbing using a helical robot. Here, we achieve mechanical rubbing of blood clots under ultrasound guidance and using external magnetic actuation. Position of the helical robot is determined using ultrasound feedback and used to control its motion toward the clot, whereas the volume of the clots is estimated simultaneously using visual feedback. We characterize the shear modulus and ultimate shear strength of the blood clots to predict their removal rate during rubbing. Our in vitro experiments show the ability to move the helical robot controllably toward clots using ultrasound feedback with average and maximum errors of ${\text{0.84}\pm \text{0.41}}$ and 2.15 mm, respectively, and achieve removal rate of $-\text{0.614} \pm \text{0.303}$ mm $^{3}$ /min at room temperature ( ${\text{25}}^{\circ }$ C) and $-\text{0.482} \pm \text{0.23}$ mm $^{3}$ /min at body temperature (37 $^{\circ}$ C), under the influence of two rotating dipole fields at frequency of 35 Hz. We also validate the effectiveness of mechanical rubbing by measuring the number of red blood cells and platelets past the clot. Our measurements show that rubbing achieves cell count of $(\text{46} \pm \text{10.9}) \times \text{10}^{4}$ cell/ml, whereas the count in the absence of rubbing is $(\text{2} \pm \text{1.41}) \times \text{10}^{4}$ cell/ml, after 40 min. |
| Databáze: | OpenAIRE |
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