Effects of age, race, sex, and smoking on prothrombin fragment 1.2 in a healthy population
| Autor: | Andrew G. Stead, Frank V. Crout, Bryant M. Moore, Bela Z. Horvath, Marcie J. Hursting |
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| Rok vydání: | 1993 |
| Předmět: | |
| Zdroj: | Clinical Chemistry. 39:683-686 |
| ISSN: | 1530-8561 0009-9147 |
| DOI: | 10.1093/clinchem/39.4.683 |
| Popis: | Prothrombin fragment 1.2 (F1.2) is a biomarker of thrombin generation during blood coagulation and has diagnostic potential for assessing thrombotic risk and monitoring anticoagulation therapy. We used a monoclonal antibody-based immunoassay for plasma F1.2 to establish a well-defined reference interval and to evaluate the effects of age, race, sex, and smoking status on F1.2 concentrations in a healthy population. Plasma samples and demographic information were obtained from 357 healthy individuals. F1.2 concentrations more closely followed a lognormal than a gaussian frequency distribution. In a multiple linear-regression model in which the logarithms of F1.2 concentrations were regressed on age, race, sex, and smoking status, the significant explanatory variables were age and, to a lesser extent, sex and smoking. A segmented "hockey stick" regression model indicated that F1.2 concentrations and age were unrelated for individuals < 44 years old but were positively correlated above that age threshold. The estimated 95% tolerance interval (P = 0.95) for F1.2 in healthy individuals < 44 years old (n = 268) was 0.21-2.78 nmol/L. We conclude that age-matched F1.2 reference intervals may be important for studies evaluating the diagnostic utility of F1.2 measurements, and that the clinical relevance of increased thrombin generation during aging warrants further investigation. |
| Databáze: | OpenAIRE |
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