Single-dose toxicity study by intra-arterial injection of 10BSH entrapped water-in-oil-in-water emulsion for boron neutron capture therapy to hepatocellular carcinoma
| Autor: | Takehisa Matsukawa, Ryouji Mizumachi, Novriana Dewi, Shin-ichiro Masunaga, Yohinori Sakurai, Kikue Mouri, Minoru Ono, Shushi Higashi, Mitsuteru Fujihara, Minoru Suzuki, Jun Nakajima, Koji Ono, Tsuyoshi Higuchi, Hiroki Tanaka, Hiroyuki Takahashi, Hironobu Yanagie, Yasuyuki Morishita, Masashi Yanagawa, Yasumasa Nonaka, Ayano Kubota, Kazuhito Yokoyama, Haruo Yamauchi, Atsuko Shinohara, Yuriko Sakurai |
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| Rok vydání: | 2020 |
| Předmět: |
Radiation
Chemistry Radiochemistry Mixing (process engineering) chemistry.chemical_element Porous glass 010403 inorganic & nuclear chemistry medicine.disease 01 natural sciences 030218 nuclear medicine & medical imaging 0104 chemical sciences 03 medical and health sciences Neutron capture 0302 clinical medicine Membrane Hepatocellular carcinoma Toxicity Emulsion medicine Boron |
| Zdroj: | Applied Radiation and Isotopes. 163:109202 |
| ISSN: | 0969-8043 |
| DOI: | 10.1016/j.apradiso.2020.109202 |
| Popis: | We developed a mixing medical device by attaching Shirasu porous glass Millipore membrane to prepare water-in-oil-in-water (WOW) emulsion in a shorter time to be applied as 10B-entrapped WOW emulsion for hepatocellular carcinoma (HCC) treatment. Single-dose toxicity studies by intra-arterial injection of 10BSH-entrapped WOW were performed in rabbits and pig, and no side effects were observed. We hope to proceed to the preclinical and clinical studies for further evaluation of 10B compound as multidisciplinary treatments for HCC. |
| Databáze: | OpenAIRE |
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