Value of Transbronchial Lung Cryobiopsy in Patients Suspicious of Peripheral Lung Cancer
| Autor: | Jiayuan Sun, Lonny Yarmus, Max Mayer, Ralf Eberhardt, Konstantinna Jkontogianni, Felix J.F. Herth, Jonas Herth |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Aspirin Lung business.industry Forceps Interstitial lung disease medicine.disease law.invention 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure 030228 respiratory system Pneumothorax Randomized controlled trial law medicine 030212 general & internal medicine Radiology Lung cancer Complication business medicine.drug |
| Zdroj: | Interventional pulmonology. |
| ISSN: | 2015-2019 |
| DOI: | 10.1183/13993003.congress-2020.3779 |
| Popis: | Transbronchial lung cryobiopsy (TLCB) is an endoscopic procedure that has proven diagnostic value for interstitial lung disease and there are published guidelines for its use. Although cryobiopsy samples have been shown to provide superior tissue samples when compared to classical forceps there remains are limited data investigating its use in suspected lung cancer. Objective: To evaluate the diagnostic yield and safety of TLCB in patients with highly suspicious of lung cancer. Methods: All patients who underwent a TLCB under general anesthesia for suspected lung cancer from 2015-2019 were recorded and retrospectively analyzed. Results: 1024 patients were underwent a TLCB procedure (259 male, mean age 58 y.). The overall diagnostic yield was 93%. 884 cases were malignant and 140 had non-malignant pathology with radiographic follow-up. The pneumothorax rate was 6.6 %. The rate of moderate to severe bleeding was 6.7 %. The complication rate was independent of the use of aspirin, probe size (1.9m m or 2.4mm) or lesion localization. Conclusions: TLCB use in suspected lung cancer cases resulted in high diagnostic yields with an acceptable complication profile. A prospective multicenter international randomized controlled trial is scheduled to accrue stating in 2020. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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