Indirect study of the effect of α-tocopherol and acetylsalicylic acid on the mineral composition of bone tissue in the offspring of female rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin: long-term observations
| Autor: | Piotr Kuropka, Marzena Styczyńska, Maciej Dobrzyński, Sara Targonska, Anna Leskow, Rafal J. Wiglusz, Małgorzata Tarnowska, Krzysztof Dudek |
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| Rok vydání: | 2019 |
| Předmět: |
Bone mineral
medicine.medical_specialty Chemistry Offspring General Chemical Engineering Calvaria 02 engineering and technology General Chemistry Mineral composition 010402 general chemistry 021001 nanoscience & nanotechnology Bone tissue 01 natural sciences Bone resorption 0104 chemical sciences medicine.anatomical_structure Endocrinology Internal medicine medicine heterocyclic compounds Composition (visual arts) Tocopherol 0210 nano-technology |
| Zdroj: | RSC Advances. 9:8016-8024 |
| ISSN: | 2046-2069 |
| Popis: | This paper discusses problems related to the influence of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the mineral composition of the calvaria in the offspring of female rats. The female rats were administered with a single dose of TCDD and subsequently, after three-weeks, with α-tocopherol or acetylsalicylic acid. The research focused on analysis of the main mineral elements (Ca, Mg, Fe, Zn). The aim of the study was to determine the effect of dioxins and various doses of drugs on bone mineral composition in a six-month observation period. The mineral composition was analyzed using an atomic spectrometry method. Data were statistically analyzed and verified at a significance level of p = 0.05. The use of α-tocopherol normalizes bone resorption and formation disturbed by TCDD, maintaining the content of the studied elements at the physiological level. In turn, administration of acetylsalicylic acid limits the bone resorption process, which affects the element content. |
| Databáze: | OpenAIRE |
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