Green Synthesis and Bioactivity of 2-Amino-4H-chromen-4-yl-phosphonates

Autor:	Mekala Rajasekhar, Chereddy Syama Sundar, Cirandur Suresh Reddy, Kunda Uma Maheswara Rao, Nemallapudi Bakthavatchala Reddy, Sandip K. Nayak
Rok vydání:	2012
Předmět:	One-pot synthesis Trimethyl phosphite chemistry.chemical_element General Chemistry General Medicine Iodine Phosphonate Catalysis chemistry.chemical_compound chemistry Salicylaldehyde Drug Discovery Mass spectrum Organic chemistry Malononitrile
Zdroj:	CHEMICAL & PHARMACEUTICAL BULLETIN. 60:854-858
ISSN:	1347-5223 0009-2363
DOI:	10.1248/cpb.c12-00160
Popis:	A simple and efficient one pot synthesis of 2-amino-4H-chromen-4-yl phosphonate derivatives has been accomplished by the condensation of salicylaldehyde, malononitrile/ethylcyanoacetate and triethyl phosphite/trimethyl phosphite in the presence of molecular iodine as catalyst in water at room temperature. All the reactions were very clean and the products were obtained in very good to excellent yields. The title compounds are characterized by IR, 1H-, 13C-, 31P-NMR and mass spectra, also studied their antimicrobial and antioxidant activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fe47dd48d6536b13e2c645f29315d3e7 https://doi.org/10.1248/cpb.c12-00160 Zobrazit plný text záznamu