Synthetic Approaches to Non-Tropane, Bridged, Azapolycyclic Ring Systems Containing Seven-Membered Carbocycles

Autor:	Aaron H. Shoemaker, Daniel R. Griffith
Rok vydání:	2020
Předmět:	Ring size chemistry.chemical_compound chemistry Stereochemistry Organic Chemistry Total synthesis Tropane Ring (chemistry) Catalysis Cycloaddition
Zdroj:	Synthesis. 53:65-78
ISSN:	1437-210X 0039-7881
DOI:	10.1055/s-0040-1707385
Popis:	This Short Review highlights various synthetic approaches to bridged azabicyclic ring systems containing seven-membered carbocyclic rings. Such ring systems are common to a number of biologically active natural products. The seven-membered ring in such systems is generally formed in one of four ways: 1) cyclization of an acyclic precursor; 2) ring expansion or rearrangement of a different ring size; 3) cycloaddition; and 4) use of a synthetic building block with the seven-membered ring already present. Representative examples of each approach from both total synthesis and methodological studies are discussed, with an emphasis on work publishedin the last twenty years.1 Introduction2 Cyclization Reactions3 Ring Expansions and Rearrangements4 Cycloadditions5 Strategies Involving Seven-Membered Ring Building Blocks6 Conclusion
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fdb4261e628aea63f1a1f0919bb6e422 https://doi.org/10.1055/s-0040-1707385 Zobrazit plný text záznamu