Synthesis and Conformation of (5R,8R,10R)-8-(Methylthiomethyl)ergoline-6-carboxamidine

Autor:	Hans-Rudolf Loosli, René Nordmann
Rok vydání:	1985
Předmět:	Stereochemistry Organic Chemistry Cyclohexane conformation Nuclear magnetic resonance spectroscopy Biochemistry Catalysis Ergoline Inorganic Chemistry chemistry.chemical_compound Thiourea chemistry Drug Discovery medicine Cyanamide Physical and Theoretical Chemistry Guanidine medicine.drug
Zdroj:	Helvetica Chimica Acta. 68:1025-1032
ISSN:	1522-2675 0018-019X
DOI:	10.1002/hlca.19850680428
Popis:	The title compound 7 and two related novel ergolines have been synthesised from (5R,8R,10R)-8-(methyl-thiomethyl)ergoline-6-carbonitrile (4). The guanidine function of 7 induces a boat conformation of ergoline-ring D, as demonstrated by a careful NMR spectroscopic analysis of 7 and its N-hydroxy congener 6. Diphenylphosphinodithioic acid has been used to convert the cyanamide function of 4 into the thiourea function at (5R,8R,10R)-8-(methylthiomethyl)ergoline-6-thiocarboxamide (5).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fcbfc1aa979ac90c13ff51445435b28a https://doi.org/10.1002/hlca.19850680428 Zobrazit plný text záznamu Plný text