Distribution of 5-HT receptors in the central nervous system: an update
| Autor: | Daniel Hoyer, Guadalupe Mengod, Roser Cortés, M T Vilaró |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Central nervous system Colocalization Biology Phenotype Ventral tegmental area 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Neurotransmitter receptor medicine Immunohistochemistry Receptor Neuroscience 030217 neurology & neurosurgery 5-HT receptor |
| DOI: | 10.1016/b978-0-444-64125-0.00006-2 |
| Popis: | Almost 10 years have passed since we wrote the review on the “Distribution of 5-HT receptors in the central nervous system” in this series ( Mengod, Cortes, Vilaro, & Hoyer, 2010 ). The number of 5-HT receptors remains the same: 14 receptor subtypes grouped in seven families. New findings are related to the identification of the phenotype of the cells expressing 5-HT receptors and their colocalization with other related neurotransmitters and neurotransmitter receptors, some in neurons, others in glial cells or astrocytes ( Zhang et al., 2010 ). The application of immunohistochemistry adds new information about this colocalization. A number of studies are centered on the expression of 5-HT receptors in brain areas related with migraine. New labeled ligands have been developed and preferentially used for positron emission tomography studies in various pathological conditions, as such molecules are considered as potential treatments and/or biomarkers for various diseases. |
| Databáze: | OpenAIRE |
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