Voltammetric Determination of Naltrexone in Pharmaceuticals
| Autor: | M.T. Fernández-Abedul, J. R. Barreira-Rodríguez, Agustín Costa-García, M. S. Velázquez-Rodríguez |
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| Rok vydání: | 1997 |
| Předmět: |
Horizontal scan rate
Reproducibility Chromatography Calibration curve Chemistry Narcotic antagonist Biochemistry (medical) Clinical Biochemistry Analytical chemistry Biochemistry Naltrexone Analytical Chemistry Carbon paste electrode Electrode Electrochemistry medicine Voltammetry Spectroscopy medicine.drug |
| Zdroj: | Analytical Letters. 30:1491-1502 |
| ISSN: | 1532-236X 0003-2719 |
| Popis: | The oxidation of naltrexone (compound used in the treatment of opioid addiction) on carbon paste electrodes has been studied using voltammetric techniques under semi-infinite linear diffusion and hydrodynamic conditions. A simple “in situ” electrode pretreatment is proposed to obtain a good reproducibility of the current signal. Subsequently, the current was measured and the concentration of naltrexone present could be determined. A linear calibration plot from 7×10−6 to 10−4M was obtained by using a scan rate of 50 mV/s. The method was succesfully applied to the determination of the compound in pharmaceuticals. |
| Databáze: | OpenAIRE |
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