The perivascular microenvironment in Epstein-Barr virus positive primary central nervous system lymphoma: The role of programmed cell death 1 and programmed cell death ligand 1
| Autor: | Yukihiko Fujii, Hideyuki Abe, Junko Miyoshi, Motohiro Morioka, Akiyoshi Kakita, Takanori Nozawa, Koichi Ohshima, Satoru Komaki, Takuya Furuta, Hitoshi Takahashi, Yasuo Sugita |
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| Rok vydání: | 2017 |
| Předmět: |
Tumor microenvironment
Primary central nervous system lymphoma FOXP3 General Medicine Biology medicine.disease_cause medicine.disease Epstein–Barr virus Pathology and Forensic Medicine Lymphoma 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis PD-L1 Immunology medicine biology.protein Cytotoxic T cell Neurology (clinical) 030217 neurology & neurosurgery B7-H1 Antigen |
| Zdroj: | Neuropathology. 38:125-134 |
| ISSN: | 0919-6544 |
| DOI: | 10.1111/neup.12435 |
| Popis: | It has been shown that high expression of certain immune checkpoint molecules, including those of the programmed death protein 1/programmed death ligand 1 (PD-1/PD-L1) axis, can be utilized to regulate immunosuppression in the microenvironment of malignant neoplasms. For the purpose of clarifying the immune-escape mechanism of primary central nervous system lymphomas (PCNSLs), particularly in Epstein-Barr virus (EBV)-positive cases, markers for PD-1, PD-L1, tumor-associated macrophages (TAMs), and tumor-infiltrating lymphocytes (TILs) in 39 surgical specimens of PCNSLs (17 EBV-positive, 22 EBV-negative) were investigated by immunohistochemistry. Staining for PD-L1 was scored as follows: (-), no staining; (1+), 0-30% positive cells; (2+), 30-60% positive cells; and (3+), >60% positive cells. In EBV-positive cases, PD-L1 was detected in both lymphoma cells and TAMs in 12/17 cases, and in TAMs only in 4/17 cases. The mean number of PD-1, TIA-1 (a marker for cytotoxic T-cells), and FOXP3 (a marker for regulatory T-cells)-positive TILs in EBV-positive cases was 36.4 ± 45.9, 390 ± 603, and 9.88 ± 15.1, respectively. In EBV-negative cases, PD-L1 was detected in both lymphoma cells and TAMs in 11/22 cases, and in TAMs only in 4/22 cases. The mean of PD-1, TIA-1 and FOXP3-positive lymphocytes in EBV-negative cases was 67.3 ± 82.0, 158 ± 206 and 9.32 ± 17.5, respectively. We found no significant difference in the number of FOXP3-positive, lymphocytes between EBV-positive and negative cases. However, there were significantly higher numbers of PD-1-positive lymphocytes in the former, and significantly higher numbers of TIA-1-positive lymphocytes in the latter (P |
| Databáze: | OpenAIRE |
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