Intérêt actuel des selective progesterone receptor modulators (SPRM) dans l’endométriose
| Autor: | R. Cabry, P. Merviel, O. Gagneur, S. Sanguin, A. Nasreddine, E. Lourdel |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
business.industry Hypoestrogenism Endometriosis Obstetrics and Gynecology Prostaglandin General Medicine medicine.disease Endometrium Anovulation chemistry.chemical_compound Endocrinology medicine.anatomical_structure Reproductive Medicine chemistry Internal medicine Progesterone receptor medicine Amenorrhea medicine.symptom business Selective Progesterone Receptor Modulators |
| Zdroj: | Gynécologie Obstétrique & Fertilité. 41:524-528 |
| ISSN: | 1297-9589 |
| Popis: | The SPRM (selective progesterone receptor modulators) are agonists and/or antagonists of progesterone receptor. They are responsible for anovulation, amenorrhea and a lower prostaglandin levels, which leads to an improvement in pain and regression of lesions in endometriosis. On the endometrium, a particular aspect, the progesterone receptor modulator-associated endometrial changes (PAEC), raises additional studies to verify its harmlessness. However, due to the lack of hypoestrogenism and metabolic effects with these drugs, it is very likely that the SPRM will in the near future an important place in the treatment of endometriosis. |
| Databáze: | OpenAIRE |
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