Preparation of a core–shell type MBHA resin and its application for solid-phase peptide synthesis

Autor:	Jang-Woong Byun, Tae Kyung Lee, Yoon-Sik Lee, Jeong-Hyun Choi
Rok vydání:	2009
Předmět:	chemistry.chemical_classification Partial hydrolysis Chemistry Organic Chemistry Peptide Biochemistry MBHA resin Core shell chemistry.chemical_compound stomatognathic system Phase (matter) Drug Discovery Peptide synthesis Organic chemistry
Zdroj:	Tetrahedron Letters. 50:4272-4275
ISSN:	0040-4039
Popis:	MBHA (4-methylbenzhydrylamine) resin has been extensively used as a solid support for the synthesis of peptide amides. Herein, we prepared the core–shell-type MBHA resin by benzotriazole-catalyzed amidoalkylation and partial hydrolysis. The core–shell structure of the MBHA resin was confirmed by two-photon microscopy and its synthetic performance in solid-phase peptide synthesis (SPPS) was evaluated.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fae5cd9b2c41989dbe84cba1ecd6b017 https://doi.org/10.1016/j.tetlet.2009.05.009 Zobrazit plný text záznamu Full Text from ScienceDirect