Arterial antithrombotic effect of piyav1t, the novel pharmacological preparation from the medicinal leech, and of its components, prostanoids and enzyme destabilase

Autor:	Omar Aguejouf, A. V. Basanova, I. P. Baskova, Fatima Azougagh-Oualane, Christian Doutremepuich, Ludmila L. Zavalova
Rok vydání:	1995
Předmět:	chemistry.chemical_classification biology Leech Prostanoid Hematology Pharmacology biology.organism_classification medicine.disease Hirudo medicinalis chemistry.chemical_compound Enzyme Biochemistry chemistry Oral administration Antithrombotic medicine Platelet Thrombus
Zdroj:	Thrombosis Research. 77:483-492
ISSN:	0049-3848
DOI:	10.1016/0049-3848(95)00024-0
Popis:	Piyavit, the novel pharmacological preparation from the medicinal leech (Hirudo medicinalis) contained the leech saliva, produces the potent arterial antithrombotic effect examined on experimental of Laser Induced Thrombus formation. Administrated orally into rats or injected subcutaneously as water extract, non-diluted or in 1600 times diluted, it inhibits statistically significant comparing with control platelet thrombus stimulated by laser beams. Its components, prostanoid fraction and purified enzyme destabilase, endo-e-(γ-Glu)-Lys-isopeptidase, also inhibit thrombus formation in statistically different manner, comparing with control. All the tested preparations inhibit platelet aggregation induced by ADP. The dependence of arterial antithrombotic effect on the leech prostanoid is discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fac3084df2d168dc5117a9b5a884a14f https://doi.org/10.1016/0049-3848(95)00024-0 Zobrazit plný text záznamu Full Text from ScienceDirect