Inhaled Corticosteroid Related Adrenal Suppression Detected by Poor Growth and Reversed by Ciclesonide
| Autor: | Brian S. Liddell, Daniel P. Hsu, John M. Oberlin |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Pituitary gland business.industry medicine.drug_class Ciclesonide Guideline medicine.disease chemistry.chemical_compound Endocrinology medicine.anatomical_structure chemistry Hypothalamus Internal medicine Adrenal insufficiency Medicine Corticosteroid Adrenal suppression business Asthma |
| Zdroj: | Section on Uniformed Services Program. |
| DOI: | 10.1542/peds.141.1_meetingabstract.751 |
| Popis: | Introduction: Hypothalamic-pituitary-adrenal (HPAA) axis suppression secondary to inhaled corticosteroids (ICS) has previously been reported, specifically with moderate or high-dose therapy. It is believed that chronic exposure to ICS may cause secondary adrenal suppression (AS) via negative feedback upon the hypothalamus and pituitary gland. It is not common to screen for AS in asthmatic patients, therefore the prevalence of ICS-induced AS is unknown. Although symptomatic adrenal insufficiency (AI) from ICS has been reported, it is considered rare. The NHLBI’s asthma guideline recommends monitoring growth in children requiring ICS, however monitoring linear growth velocity (GV) has not … |
| Databáze: | OpenAIRE |
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