Unimpaired postprandial pancreatic polypeptide secretion in Parkinson's disease and REM sleep behavior disorder

Autor: Peter H. Kann, Anna‐Karin Björklund, Karin Stiasny-Kolster, Johannes J. Tebbe, Jens Carsten Möller, Geert Mayer, Gösta Karlsson, Katharina Bohne, Rolf Ekman, Wolfgang H. Oertel, Katharina Mankel, Marcus M. Unger, Chatarina Andersson
Rok vydání: 2012
Předmět:
Zdroj: Movement Disorders. 28:529-533
ISSN: 0885-3185
DOI: 10.1002/mds.25246
Popis: Background: Pancreatic polypeptide is released immediately after food ingestion. The release is operated by vagal-abdominal projections and has therefore been suggested as a test for vagal nerve integrity. Pathoanatomical and clinical studies indicate vagal dysfunction in early Parkinson's disease (PD). Methods: We assessed the postprandial secretion of pancreatic polypeptide and motilin in healthy controls (n = 18) and patients with idiopathic rapid-eye-movement sleep behavior disorder (iRBD, n = 10), a potential premotor stage of PD, as well as in drug-naive (n = 19) and treated (n = 19) PD patients. Results: The postprandial pancreatic polypeptide secretion showed a physiological pattern in all groups and even an enhanced response in drug-naive PD and iRBD. Motilin concentrations correlated with pancreatic polypeptide concentrations. Conclusions: Postprandial pancreatic polypeptide secretion is not a suitable test for vagal nerve integrity in PD. The unimpaired pancreatic polypeptide response in iRBD and PD might be explained by partially intact vagal-abdominal projections or compensatory mechanisms substituting a defective neuronal brain–gut axis. © 2012 Movement Disorder Society
Databáze: OpenAIRE
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