Dimephosphone analogs: a pharmacological aspect

Autor: V. N. Nabiullin, B. I. Buzykin, D. A. Tatarinov, L. R. Kashapov, R. S. Garaev, R. V. Chestnova, A. V. Il\\'yasov, V. V. Zobova, Vladimir F. Mironov
Rok vydání: 2014
Předmět:
Zdroj: Russian Chemical Bulletin. 63:2114-2125
ISSN: 1573-9171
1066-5285
DOI: 10.1007/s11172-014-0708-2
Popis: We studied some pharmacological properties of dimephosphone P—C and aza analogs, viz., dimethyl (2-methyl-4-oxopent-2-yl)phosphonate, which is one of the first organophosphorus drugs having no anticholinesterase activity. Replacement of two P—O—C fragments in dialkyl (2-methyl-4-oxopent-2-yl)phosphonates with the P—C ones on going to dialkyl-(2-methyl-4-oxopent-2-yl)phosphine oxides results in a dramatic decrease in the acute toxicity of the latter to warmblooded animals. The toxicities of dimephosphone aza analogs and (γ-oxoalkyl)phosphine oxides under study depend on the nature of aza fragment introduced instead of the oxygen atom. Dimephosphone pyridinoylhydrazones were found to exhibit a high antiinflammatory activity, which increases the interest for this type compounds as promising tuberculostatics.
Databáze: OpenAIRE
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