INTRA-CAVITY INTRODUCTION OF METHOTREXATE IN COMPLEX THERAPY OF THYROID CYSTS

Autor: A. G. Grintsov, V. B. Akhrameyev, Yu. L. Kunitsky, A. B. Matiytsiv, A. A. Khristulenko
Rok vydání: 2020
Předmět:
Zdroj: Tavricheskiy Mediko-Biologicheskiy Vestnik. 23:59-63
ISSN: 2070-8092
DOI: 10.37279/2070-8092-2020-23-2-59-63
Popis: The development and implementation of new more effective minimally invasive technologies for the treatment of simple thyroid cysts is current. evaluating the effectiveness of a method of treating simple thyroid cysts involving echo-assisted puncture, evacuation of contents and subsequent introduction of methotrexate into a cavity. The results of examination and treatment of 67 patients suffering from thyroid cysts are presented. Asymptomatic flow was noted in the majority of 61 (91.04%) patients, 4 (4.99%) - noted swallowing, and 2 (2.97%) - difficulty swallowing. For the first time, 42 (55.26%) patients independently identified their education, and 34 (44.74%) during a preventive medical examination. When echo-examined, all patients showed cystic thyroid masses, the average size of which was 20.8±8.3 mm. Outpatient in aseptic conditions under the control of ultrasound, puncture aspiration of the contents was carried out and subsequent intra-cavity administration of methotrexate solution with a cytostatic content of 20 mg to 30 mg. The volume of methotrexate introduced corresponded to the amount of aspirated liquid - 11.9 ± 3.8 ml (range from 2.5 to 16.2 ml). With control sonography, performed a month after the intervention in 51 (76.12%) cases, cystic formation was not visualized, in 5 (7.46%) - the maximum size of the latter did not exceed 9 mm, in 11 (16.42%) cases - the cavity decreased by no more than one third. After 12 months with a control ultrasound, all cystic masses underwent regression: in 61 (91.04%) cases, no masses were echo-visualized, in 3 (4.48%) - the maximum size of the latter did not exceed 9 mm. High efficiency (no formation or reduction of the latter to 9 mm) in 95,52% of cases is echo-proved.
Databáze: OpenAIRE