Two Metabolites with DNA-Binding Affinity from the Mangrove FungusXylariasp. (#2508) from the South China Sea Coast

Autor:	Bingtai Lu, E. B. Gareth Jones, Zhigang She, Yongcheng Lin, L. L. P. Vrijmoed, Jiajun Wang, Jiyan Pang, Fang Xu, Yi Zhang
Rok vydání:	2009
Předmět:	South china biology Stereochemistry Metabolite Intercalation (chemistry) General Chemistry Fungus biology.organism_classification Xylaria sp Affinities chemistry.chemical_compound chemistry Mangrove DNA
Zdroj:	Chinese Journal of Chemistry. 27:365-368
ISSN:	1614-7065 1001-604X
DOI:	10.1002/cjoc.200990059
Popis:	A novel metabolite xylopyridine A (1), together with a known compound pyrocoll (2), was isolated from mangrove endophytic fungus Xylaria sp. (#2508) collected from the South China Sea coast. Their structures were established on the basis of spectroscopic analysis, especially 2D-NMR. Their affinities toward calf thymus (CT) DNA were studied by fluorescence quenching and spectrophotometric titration experiments. The results indicate that 1 showes strong DNA-binding affinity presumably via an intercalation mechanism, thus it is exploitable as strong DNA-binders.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f95af601d146d365ce7c3f90f76b9cfa https://doi.org/10.1002/cjoc.200990059 Zobrazit plný text záznamu Plný text