Deciphering the Biosynthetic Mechanism of Pelletierine in Lycopodium Alkaloid Biosynthesis
| Autor: | Ze-Kun Zhang, Hiroyuki Morita, Xiao Liu, Ikuro Abe, Ning Ding, Saw Yu Yu Hnin, Pengfei Tu, Shepo Shi, Juan Wang, Xiaohui Wang, Fangfang Jiang, Jun Li, Bowen Qi |
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| Rok vydání: | 2020 |
| Předmět: |
Lycopodium
biology 010405 organic chemistry Stereochemistry Organic Chemistry Stereoisomerism Huperzia serrata 010402 general chemistry biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences chemistry.chemical_compound Biosynthesis chemistry Phlegmariurus cryptomerianus Pelletierine Physical and Theoretical Chemistry Lycopodium alkaloid |
| Zdroj: | Organic Letters. 22:8725-8729 |
| ISSN: | 1523-7052 1523-7060 |
| Popis: | Pelletierine, a proposed building block of Lycopodium alkaloids (LAs), was demonstrated to be synthesized via the non-enzymatic Mannich-like condensation of Δ1-piperideine and 3-oxoglutaric acid produced by two new type III PKSs (HsPKS4 and PcPKS1) characterized from Huperzia serrata and Phlegmariurus cryptomerianus, respectively. The findings provide new insights for further understanding the biosynthesis of LAs such as huperzine A. |
| Databáze: | OpenAIRE |
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