Synthesis and characterisation of poly (l-lactic acid) galactosyl derivatives; access to functionalised microspheres

Autor:	Hatem Fessi, Rima Kassab, Bernard Fenet, Hélène Parrot-Lopez
Rok vydání:	2000
Předmět:	Poly l lactic acid chemistry.chemical_classification Chemistry Carboxylic group Organic Chemistry Acid–base titration Peptide Polymer Biochemistry Combinatorial chemistry Microsphere Gel permeation chromatography Drug Discovery Proton NMR Organic chemistry
Zdroj:	Tetrahedron Letters. 41:877-881
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(99)02216-9
Popis:	A new series of galactosyl-derived polymers has been used for the preparation of microspheres. The strategy is based on the modification of the terminal carboxylic group l-PLA (73.000) by coupling to a galactosyl antenna in the presence of the peptide coupling agents: DCC/HOBT. The degree of functionalisation varies between 60 and 70%, and antenna density between 1.74 and 2.78. The characterisations of the new products were carried out using 1H NMR, gel permeation chromatography, and acid base titration; the size of the functionalised microspheres was determined to be 210–270 μm by DLS.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f7e1bc424b58b55acdeeb23ebda20595 https://doi.org/10.1016/s0040-4039(99)02216-9 Zobrazit plný text záznamu Full Text from ScienceDirect