Bringing down the host: enteropathogenic and enterohaemorrhagicEscherichia colieffector-mediated subversion of host innate immune pathways

Autor:	Andrew S. Santos, B. Brett Finlay
Rok vydání:	2015
Předmět:	0303 health sciences Innate immune system 030306 microbiology Effector Host (biology) Phagocytosis Immunology Virulence biochemical phenomena metabolism and nutrition Biology bacterial infections and mycoses Microbiology 3. Good health Immune tolerance 03 medical and health sciences Intestinal mucosa Virology bacteria Secretion 030304 developmental biology
Zdroj:	Cellular Microbiology. 17:318-332
ISSN:	1462-5814
Popis:	Enteric bacterial pathogens commonly use a type III secretion system (T3SS) to successfully infect intestinal epithelial cells and survive and proliferate in the host. Enteropathogenic and enterohaemorrhagic Escherichia coli (EPEC; EHEC) colonize the human intestinal mucosa, form characteristic histological lesions on the infected epithelium and require the T3SS for full virulence. T3SS effectors injected into host cells subvert cellular pathways to execute a variety of functions within infected host cells. The EPEC and EHEC effectors that subvert innate immune pathways--specifically those involved in phagocytosis, host cell survival, apoptotic cell death and inflammatory signalling--are all required to cause disease. These processes are reviewed within, with a focus on recent work that has provided insights into the functions and host cell targets of these effectors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f6debe25d16c8497cfe1b0cd37990adc https://doi.org/10.1111/cmi.12412 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.