C60-Based Ebselen Derivative: Synthesis and Enhanced Protective Effect on Mouse Thymus Cells

Autor: Wen‐Shan Ke, Wen‐Chao Guan, Xu‐Feng Liu
Rok vydání: 2008
Předmět:
Zdroj: Chinese Journal of Chemistry. 26:225-228
ISSN: 1614-7065
1001-604X
DOI: 10.1002/cjoc.200890030
Popis: A C60-based ebselen derivative 3 was synthesized through a Bingel cyclopropanation of C60 with the ebselen malonate 2. It was obtained in a three-step synthesis starting from 2-(chloroseleno)benzoyl chloride and 2-(2-aminoethoxy)ethanol, in a 42% yield (based on consumed C60). Its structure was characterized by 1H NMR, 13C NMR, IR, FAB-MS, and elemental analyses techniques. To verify that the C60-based ebselen derivative 3 had enhanced effect on viability of mouse thymus cells, the C60 derivative 4 and ebselen derivative 2 were selected to treat the mouse thymus cells using the same procedures as those with the C60-based ebselen derivative 3. The result shows that MTT(OD) values of compound 3 treated groups (0.335±0.021) were all higher than those of compound 4 (0.283±0.031) and compound 2 (0.247±0.025) treated groups, indicating that the compound 3 has an advantage over compounds 2 and 4 in promoting the viability of the mouse thymus cell.
Databáze: OpenAIRE
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