Comparison and Correlation of CD4T Cells Countwith Viral Load Prior to and after Initiating HAART in HIV Iraqi Patients

Autor:	Mothana Ali Khalil, Aliaa Hussain Lafi
Rok vydání:	2020
Předmět:	Efavirenz Elvitegravir business.industry Cobicistat virus diseases Emtricitabine medicine.disease Tenofovir alafenamide Virology Pathology and Forensic Medicine chemistry.chemical_compound chemistry Acquired immunodeficiency syndrome (AIDS) medicine business Viral load Didanosine medicine.drug
Zdroj:	Medico-Legal Update.
ISSN:	0974-1283 0971-720X
DOI:	10.37506/mlu.v20i2.1145
Popis:	Background: HIV that cause of AIDS worldwide distributed and the CD4 positive T cells consider chieftarget cells of HIV. Elimination of HIV is the final goal of HIV treatment, but is rarely achieved.Objective: As CD4T cells count using flow cytometry recently available, we investigated whether CD4Tcells count can substitute for HIV plasma viral load RNA quantification in treatment monitoring throughcomparison the change in CD4 positive T cells count in patients with HIV previous to & afterward initiating?highly/active/antiviral/therapy ??HAART? & correlation of CD4 T cellscounts with viral load prior to andafter initiating HAART in HIV Iraqi patients.Method: Within this study, 25 HIV patients were prospectively analyzed. Patients have been treated withBilateral/Didanosine, combination (Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate), inaddition to Quadruple combination (Elvitegravir,cobicistat,emtricitabine,tenofovir alafenamide (TAF).Quantitative CD4T cells countwere determined with flowcytometry. HIV plasma viral load RNA weredetermined with RT-PCR at given time points.Results: We find weak negativenon-significant? correlation?(R?-0.267, p? 0. 197 & R?-0.161, p?0. 441)among CD4positive T cellscounts & ?plasma viral load of HIV RNA?in both treated and untreated patientsrespectively. More importantly, there was significant concordance between an increase or decrease of CD4Tcells counts with HIV RNA plasma viral load prior and after initiating of treatment. However, the curve andincrease of CD4T cells count enabled prediction of eventual of viral clearance.Conclusions: Quantitative CD4T cells count cannot substitute for HIV RNA plasma viral load quantificationduring assessment of antiviral therapy: However, the increase of CD4 T cells count does predict eventualHIV RNA plasma clearance. A 2 log 10 increase to above 200 IU/ml is associated with a high likelihood ofHIV plasma RNA clearance.
Databáze:	OpenAIRE
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