Tissue ferritin concentration in breast carcinoma: A possible marker of proliferative index (A cytosol and Electron Microscopic study)

Autor:	Mary C. Elliott, Debra Werneke, Lindsay Ledford, Robert L. Elliott
Rok vydání:	1989
Předmět:	Ferritin Pathology medicine.medical_specialty Cytosol Proliferative index biology business.industry medicine biology.protein General Medicine Breast carcinoma business Electron microscopic
Zdroj:	Proceedings, annual meeting, Electron Microscopy Society of America. 47:852-853
ISSN:	2690-1315 0424-8201
DOI:	10.1017/s0424820100156249
Popis:	Elevation of serum ferritin in carcinoma of the breast is well known and levels suggest the severity of the disease. Weinstein et al. found that malignant tissue had six times the ferritin concentration as did benign breast tissue. Malignancies with the highest ferritin concentration were histologically more anaplastic suggesting that the major site of the increased ferritin was the malignant epithelium. They postulated that ferritin may be a marker of neoplasia.To confirm and expand on this study and increase our knowledge on the role of transferrin receptors and iron metabolism in breast cancer, we measured tissue ferritin in cytosol extracts in 44 mammary carcinomas and 11 benign breast tissues. All specimens were examined ultrastructurally. Ferritin concentrations in malignant specimens ranged from 192-12,308 ng/mcp while in benign tissue it ranged from 33-296 ng/mcp. Electron microscopy showed abundant ferritin deposits in malignant epithelium while deposits were sparse in benign epithelium and connective tissue stroma.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f642837f80bce0e57e8100f0243cfa38 https://doi.org/10.1017/s0424820100156249 Zobrazit plný text záznamu