Ultrasound characteristics of endometrial cancer as defined by International Endometrial Tumor Analysis (IETA) consensus nomenclature: prospective multicenter study
| Autor: | Valentina Chiappa, Joseph W. Carlson, Maria Angela Pascual, Juan Luis Alcázar, G. Opolskiene, Pelle G. Lindqvist, Floriana Mascilini, Elisabeth Epstein, Robert Fruscio, L.A. Haak, F. P. Giuseppe Leone, B. Van Calster, Lil Valentin, B. De Moor, Daniela Fischerova, T. Van den Bosch, A. C. Testa, D. Timmerman, Dorella Franchi, Tom Bourne, Povilas Sladkevicius, F. Frühauf, A. Installe, Stefano Guerriero, Jan Y Verbakel, C. Van Holsbeke |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment 03 medical and health sciences 0302 clinical medicine Medicine Radiology Nuclear Medicine and imaging Vaginal bleeding Stage (cooking) Prospective cohort study Gynecology 030219 obstetrics & reproductive medicine Hysterectomy Radiological and Ultrasound Technology business.industry Endometrial cancer Obstetrics and Gynecology Echogenicity General Medicine medicine.disease Reproductive Medicine 030220 oncology & carcinogenesis Median body Radiology medicine.symptom business Endometrial Neoplasm |
| Zdroj: | Ultrasound in Obstetrics & Gynecology. 51:818-828 |
| ISSN: | 0960-7692 |
| DOI: | 10.1002/uog.18909 |
| Popis: | Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd. Objective: To describe the sonographic features of endometrial cancer in relation to tumor stage, grade and histological type, using the International Endometrial Tumor Analysis (IETA) terminology. Methods: This was a prospective multicenter study of 1714 women with biopsy-confirmed endometrial cancer undergoing standardized transvaginal grayscale and Doppler ultrasound examination according to the IETA study protocol, by experienced ultrasound examiners using high-end ultrasound equipment. Clinical and sonographic data were entered into a web-based database. We assessed how strongly sonographic characteristics, according to IETA, were associated with outcome at hysterectomy, i.e. tumor stage, grade and histological type, using univariable logistic regression and the c-statistic. Results: In total, 1538 women were included in the final analysis. Median age was 65 (range, 27–98) years, median body mass index was 28.4 (range 16–67) kg/m2, 1377 (89.5%) women were postmenopausal and 1296 (84.3%) reported abnormal vaginal bleeding. Grayscale and color Doppler features varied according to grade and stage of tumor. High-risk tumors, compared with low-risk tumors, were less likely to have regular endometrial–myometrial junction (difference of −23%; 95% CI, −27 to −18%), were larger (mean endometrial thickness; difference of +9%; 95% CI, +8 to +11%), and were more likely to have non-uniform echogenicity (difference of +7%; 95% CI, +1 to +13%), a multiple, multifocal vessel pattern (difference of +21%; 95% CI, +16 to +26%) and a moderate or high color score (difference of +22%; 95% CI, +18 to +27%). Conclusion: Grayscale and color Doppler sonographic features are associated with grade and stage of tumor, and differ between high- and low-risk endometrial cancer. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text