NLRC5 regulates MHC-I expression and immunity during viral infection (APP3P.101)
| Autor: | Christopher Lupfer, Kate Stokes, Thirumala-Devi Kanneganti |
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| Rok vydání: | 2015 |
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| Zdroj: | The Journal of Immunology. 194:113.2-113.2 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.194.supp.113.2 |
| Popis: | NLRC5 is a member of the NOD-Like receptor family and reportedly functions in the regulation of type I interferons and inflammasome activation. In addition, NLRC5 functions as a transcriptional transactivator of MHC-I gene expression. We have observed that Nlrc5-deficient mice infected with influenza A virus have normal type I interferon responses and inflammasome activation but have dramatically reduced H-2Db and H-2Kb major histocompatibility complex (MHC)-I allele expression on virtually all myeloid and lymphoid cells. Furthermore, Nlrc5-/- mice have diminished capacity for CD8+ T cell responses directed toward influenza A virus following infection. These data suggest that during influenza A virus infection, NLRC5 plays an important function in the generation of adaptive immunity but has no detectable role in the innate immune response. |
| Databáze: | OpenAIRE |
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