| Autor: | J. W. Gorrod, Jim Fang |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Drug
CYP2D6 biology business.industry media_common.quotation_subject medicine.medical_treatment Cytochrome P450 Cell Biology General Medicine Metabolism Pharmacology Cellular and Molecular Neuroscience biology.protein Medicine Enzyme inducer business Antipsychotic Pharmacogenetics Active metabolite media_common |
| Zdroj: | Cellular and Molecular Neurobiology. 19:491-510 |
| ISSN: | 0272-4340 |
| DOI: | 10.1023/a:1006938908284 |
| Popis: | 1. Antipsychotic drugs are extensively metabolised by cytochrome P450 (CYP) enzymes. 2. Dispositions of a number of antipsychotic drugs have been shown to cosegregate with polymorphism of CYP2D6. 3. Metabolic drug–drug interactions have frequently been observed when antipsychotics are coadministered with other drugs. 4. Many antipsychotic drugs are converted to active metabolites which can contribute to the therapeutic or side effects of the parent drug. 5. Information concerning the individual CYP isoenzymes involved in the metabolism of antipsychotic drugs is important for the safe clinical use of this group of drugs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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