Oxa-prostanoid analogs. Identification of an orally effective, dual thromboxane receptor antagonist /thromboxane synthase inhibitor

Autor:	Ronald Dotson, Frank H Clarke, Isidoros Vlattas, J. Mathis, W. Lee, David Cohen, H. Zoganas, James Dellureficio
Rok vydání:	1994
Předmět:	Long lasting biology Organic Chemistry Clinical Biochemistry Pharmaceutical Science Prostanoid Pharmacology Biochemistry Thromboxane receptor antagonist chemistry.chemical_compound chemistry Drug Discovery biology.protein Molecular Medicine Thromboxane-A synthase Molecular Biology
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 4:2073-2076
ISSN:	0960-894X
DOI:	10.1016/s0960-894x(01)80104-9
Popis:	The synthesis and pharmacological evaluation of oxa-prostanoid analogs with dual thromboxane receptor antagonist (TxRA)/thromboxane synthase inhibitor (TxSI) activities are described. One analog 6 with the desirable long lasting oral TxRA/TxSI activity has been identified.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f531e1a35eafad7b03867b2278a0f026 https://doi.org/10.1016/s0960-894x(01)80104-9 Zobrazit plný text záznamu