A facile method for deprotection of trityl ethers using column chromatography

Autor:	Robert C. Reynolds, Kamal N. Tiwari, M. S. Akhtar, Ashish K. Pathak, Vibha Pathak, Lainne E. Seitz
Rok vydání:	2001
Předmět:	chemistry.chemical_compound Chromatography Column chromatography Acid sensitive Chemistry Silica gel Organic Chemistry Drug Discovery Trifluoroacetic acid Acid stable Biochemistry
Zdroj:	Tetrahedron Letters. 42:7755-7757
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(01)01645-8
Popis:	A mild, efficient and inexpensive detritylation method is reported that uses trifluoroacetic acid on a silica gel column to obtain pure, detritylated compounds in one-step. This method is applicable to acid stable as well as acid sensitive compounds with only slight alterations in the procedure. Nineteen examples are given.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f21a77a57c95e0dab8285aa41092239c https://doi.org/10.1016/s0040-4039(01)01645-8 Zobrazit plný text záznamu Full Text from ScienceDirect