Substrate-related phosphonopeptides, a new class of thrombin inhibitors
| Autor: | Christopher A. Goodwin, Michael F. Scully, Vijay V. Kakkar, Goran Claeson, Leifeng Cheng |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
chemistry.chemical_classification
Dipeptide biology Stereochemistry Peptidomimetic Organic Chemistry Biochemistry Amino acid chemistry.chemical_compound Thrombin Enzyme chemistry Enzyme inhibitor mental disorders Drug Discovery medicine Side chain biology.protein medicine.drug Discovery and development of direct thrombin inhibitors |
| Zdroj: | Tetrahedron Letters. 32:7333-7336 |
| ISSN: | 0040-4039 |
| Popis: | Novel phosphorus-containing peptidomimetics, D-Aa-Pro-Aa P (OPh) 2 , with lipophilic amino acids at the P 3 positions 1 and amino phosphonic acids with neutral side chains in the P 1 position have been designed and synthesized as thrombin inhibitors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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