ONE-POT SYNTHESIS OF A NOVEL TETRACYCLIC RING SYSTEM: BENZOPYRANO-1,2,4-TRAZOL0[3,4-B][1,3,4] THIADIAZEPINES AND THEIR ANTIFUNGAL ACTIVITY

Autor:	Mani Upreti, Mitali Saha, Asha Shivpuri, Anshu Dandia
Rok vydání:	1998
Předmět:	biology Stereochemistry Organic Chemistry One-pot synthesis Colletotrichum capsici biology.organism_classification Biochemistry Toluene In vitro Catalysis Inorganic Chemistry Rhizoctonia solani chemistry.chemical_compound chemistry Fusarium oxysporum Piperidine
Zdroj:	Phosphorus, Sulfur, and Silicon and the Related Elements. 143:115-124
ISSN:	1563-5325 1042-6507
DOI:	10.1080/10426509808045490
Popis:	A series of novel 11-alkyl-2-chloro-6a, 7-dihydro-6H-7(4-aryl)-6-phenyl[1]benzopyrano-1,2,4-triazolo[3,4-b]benzothiadiazepines(IV) have been synthesized by the reaction of 4-amino-5-alkyl-3-mercapto-1,2,4-triazoles (I) with (E)-6-chloro-3-(4-chloro/methoxy-benzyLidene)flavanones (IIa/b) in refluxing toluene, containing piperidine as catalyst. The compounds have been characterized on the basis of elemental and spectral studies and have been screened in vitro for antifungal activity against Rhizoctonia solani, Fusarium oxysporum and Colletotrichum capsici. All the compounds have shown excellent activity against these pathogens.
Databáze:	OpenAIRE
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