Synthesis of carbon-14 labelled NK-1 receptor antagonists GR203040 and GR205171

Autor:	Karl M. Cable, Derek R. Sutherland, Guy N. Wells
Rok vydání:	2000
Předmět:	Stereochemistry Organic Chemistry Antagonist chemistry.chemical_element Cyanation Biochemistry Chemical synthesis Analytical Chemistry Catalysis chemistry NK 1 Receptor Antagonists Drug Discovery Radiology Nuclear Medicine and imaging Carbon-14 Receptor Spectroscopy Palladium
Zdroj:	Journal of Labelled Compounds and Radiopharmaceuticals. 43:29-45
ISSN:	1099-1344 0362-4803
DOI:	10.1002/(sici)1099-1344(200001)43:1<29::aid-jlcr288>3.0.co;2-r
Popis:	Syntheses of carbon-14 labelled versions of NK-1 receptor antagonists GR203040 and GR205171 are described. The carbon-14 atoms were introduced by palladium (0) catalysed cyanation of iodoaromatic substrates. Copyright © 2000 John Wiley & Sons, Ltd.
Databáze:	OpenAIRE
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