Sex chromosome markers: Characterization using fluorescence in situ hybridization and review of the literature

Autor: Nelson B. Isada, Theresa W. Depinet, Vickie L. Zurcher, Evelyn M. Karson, Richard Stallard, Julie Leana-Cox, Linda M. Pasztor, Joleen L. Zackowski, Daynna J. Wolff, Vicki M. Park, Arthur B. Zinn, Linda C. Sheppard, Stuart Schwartz
Rok vydání: 1997
Předmět:
Zdroj: American Journal of Medical Genetics. 71:1-7
ISSN: 1096-8628
0148-7299
Popis: Fluorescence in situ hybridization (FISH) using biotin labeled X- and Y-chromosome DNA probes was utilized in the analysis of 23 sex chromosome-derived markers. Specimens were obtained through prenatal diagnosis, because of a presumptive diagnosis of Ullrich-Turner syndrome, mental retardation, and minor anomalies or ambiguous genitalia; three were spontaneous abortuses. Twelve markers were derived from the X chromosome and eleven from the Y chromosome; this demonstrates successfully the value and necessity of FISH utilizing DNA probes in the identification of sex chromosome markers. Both fresh and older slides, some of which had been previously G-banded, were used in these determinations. We have also reviewed the literature on sex chromosome markers identified using FISH.
Databáze: OpenAIRE
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