Optical and photophysical properties of the chlorin-type photosensitizer photolon in aqueous solutions of different acidities
| Autor: | Irina V. Martynenko, I. V. Bagrov, T. K. Kris’ko, Inna M. Belousova, A. V. Dadeko, E. V. Kriukova, M. R. Savchenko |
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| Rok vydání: | 2017 |
| Předmět: |
Aqueous solution
Chemistry medicine.medical_treatment Photodynamic therapy 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Photochemistry 01 natural sciences Fluorescence Atomic and Molecular Physics and Optics 0104 chemical sciences Electronic Optical and Magnetic Materials chemistry.chemical_compound Distilled water Excited state Chlorin medicine Photosensitizer 0210 nano-technology Visible spectrum |
| Zdroj: | Optics and Spectroscopy. 123:392-398 |
| ISSN: | 1562-6911 0030-400X |
| DOI: | 10.1134/s0030400x17090041 |
| Popis: | Photolon is a modern compound for fluorescence diagnostics and photodynamic therapy, which was relatively recently introduced into clinical practice. In the present work, we study its electronic-absorption spectra, fluorescence spectra (excited at different visible wavelengths), and fluorescence quantum yields. The characteristics are studied in aqueous solutions with pH 6.0–7.5 and compared under identical conditions with the corresponding characteristics of other chlorin- or porphyrin-type compounds (Photoditazin, Radachlorin, Dimegin) for photodynamic diagnostics and therapy. It is shown that the studied properties of Photolon are very close to those of Photoditazin and Radachlorin. At the same time, chlorin products are found to be more effective than Dimegin at pH 7.5, which is close to the pH of blood, while Dimegin is the most effective in solutions with lower pH, for example, in distilled water. |
| Databáze: | OpenAIRE |
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