Using a Systems-Based Risk Score Approach to Examine Genetic Predisposition to Novelty Seeking
| Autor: | Bradley T. Conner, Terry Ritchie, Gerhard Hellemann, Abigail C. Demianczyk, Ernest P. Noble |
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| Rok vydání: | 2017 |
| Předmět: |
Multivariate statistics
Framingham Risk Score Mechanism (biology) media_common.quotation_subject 05 social sciences Novelty seeking Genome-wide association study Mental illness medicine.disease 050105 experimental psychology Developmental psychology 03 medical and health sciences 0302 clinical medicine medicine Genetic predisposition Personality 0501 psychology and cognitive sciences Psychology 030217 neurology & neurosurgery Biological Psychiatry General Psychology media_common |
| Zdroj: | Journal of Individual Differences. 38:163-174 |
| ISSN: | 2151-2299 1614-0001 |
| DOI: | 10.1027/1614-0001/a000233 |
| Popis: | Abstract. Previous research is mixed regarding the relation between dopamine and Novelty Seeking. The goals of the current study were to support the hypotheses that Novelty Seeking is associated with dopamine genes and that modeling genetic risk score increases the utility of genetic information in hypothesis-driven research. The results showed that higher hypodopaminergic genetic risk score positively predicted higher Novelty Seeking score, F(1, 115) = 5.76, p 2 = 0.06. The findings support study hypotheses and, in combination with previous studies, show the utility of empirically validated system-based risk scores as a means of modeling genetic predisposition in neurobiological systems. This approach provides a mechanism for incorporating genetic predisposition into theory-driven multivariate etiological models of psychological constructs such as personality and mental illness. |
| Databáze: | OpenAIRE |
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