Desymmetrization of meso-Bicyclic Hydrazines: An Efficient Strategy towards the Synthesis of Functionalized Cyclopentenes

Autor:	Kokkuvayil Vasu Radhakrishnan, V. S. Sajisha, Jubi John, Saithalavi Anas
Rok vydání:	2009
Předmět:	Hydroboration Bicyclic molecule Chemistry Reagent Organic Chemistry chemistry.chemical_element Reactivity (chemistry) Combinatorial chemistry Desymmetrization Palladium
Zdroj:	Synlett. 2009:2885-2895
ISSN:	1437-2096 0936-5214
DOI:	10.1055/s-0029-1218287
Popis:	Desymmetrization of MESO-bicyclichydrazines offers a facile entry into the class of functionalizedcyclopentenes. Various methodologies used along this direction aredescribed in this account. Our attempts in this area proved thatthe palladium-catalyzed desymmetrization of these substrates withvarious organometallic reagents results in the formation of 3,4-disubstitutedcyclopentenes. 1 Introduction and Background 1.1 Hydroarylation 1.2 Hydroboration 1.3 Acid-Catalyzed Transformations 2 Our Efforts 2.1 Reactions with Organostannanes 2.2 Reactions with Organosilanes 2.3 Reactions with Organoboronic Acids 2.4 Reactions with Organoindium Reagents 2.5 Reactivity of Pentafulvene-Derived Bicyclic Hydrazines 2.6 Reactions with Organoaluminum and Organozinc Reagents 2.7 Reactions with ORTHO-FunctionalizedAryl Iodides 2.8 Mechanistic Pathway 3 Conclusion
Databáze:	OpenAIRE
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