A multiscale method for a robust detection of the default mode network
| Autor: | Jean-Flory Tshibanda, Katherine Baquero, Olivia Gosseries, Athena Demertzi, Francisco Gómez, Quentin Noirhomme, Steven Laureys, Audrey Vanhaudenhuyse, Christian Cifuentes, Eduardo Romero, Andrea Soddu, Pieter Guldenmund |
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| Rok vydání: | 2013 |
| Předmět: |
Quantitative Biology::Neurons and Cognition
Resting state fMRI medicine.diagnostic_test business.industry Computer science Pattern recognition Signal-to-noise ratio Goodness of fit medicine Preprocessor Artificial intelligence Sensitivity (control systems) business Functional magnetic resonance imaging Smoothing Default mode network |
| Zdroj: | SPIE Proceedings. |
| ISSN: | 0277-786X |
| DOI: | 10.1117/12.2035519 |
| Popis: | The Default Mode Network (DMN) is a resting state network widely used for the analysis and diagnosis of mental disorders. It is normally detected in fMRI data, but for its detection in data corrupted by motion artefacts or low neuronal activity, the use of a robust analysis method is mandatory. In fMRI it has been shown that the signal-to-noise ratio (SNR) and the detection sensitivity of neuronal regions is increased with di erent smoothing kernels sizes. Here we propose to use a multiscale decomposition based of a linear scale-space representation for the detection of the DMN. Three main points are proposed in this methodology: rst, the use of fMRI data at di erent smoothing scale-spaces, second, detection of independent neuronal components of the DMN at each scale by using standard preprocessing methods and ICA decomposition at scale-level, and nally, a weighted contribution of each scale by the Goodness of Fit measurement. This method was applied to a group of control subjects and was compared with a standard preprocesing baseline. The detection of the DMN was improved at single subject level and at group level. Based on these results, we suggest to use this methodology to enhance the detection of the DMN in data perturbed with artefacts or applied to subjects with low neuronal activity. Furthermore, the multiscale method could be extended for the detection of other resting state neuronal networks. |
| Databáze: | OpenAIRE |
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