Non-natural 2H-azirine-2-carboxylic acids: an expedient synthesis and antimicrobial activity
| Autor: | Alexander N. Koronatov, Pavel A. Sakharov, Vladimir V. Sharoyko, Elizaveta V. Rogacheva, Alexander F. Khlebnikov, Mikhail S. Novikov, Nikolai V. Rostovskii, Tatiana B. Tennikova, Liudmila Kraeva, Artem G. Glukharev |
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| Rok vydání: | 2019 |
| Předmět: |
Azirine
General Chemical Engineering 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology Antimicrobial 01 natural sciences 0104 chemical sciences chemistry.chemical_compound Hydrolysis chemistry Organic chemistry 0210 nano-technology Cytotoxicity Antibacterial activity Isomerization |
| Zdroj: | RSC Advances. 9:37901-37905 |
| ISSN: | 2046-2069 |
| Popis: | Non-natural 2H-azirine-2-carboxylic acids were obtained in high yields by FeCl2-catalyzed isomerization of 5-chloroisoxazoles to azirine-2-carbonyl chlorides followed by their hydrolysis. The 3-aryl- and 3-heteroaryl-substituted acids are stable during prolonged storage, exhibit antibacterial activity against ESKAPE pathogens and show a low level of cytotoxicity. |
| Databáze: | OpenAIRE |
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