Molecular Mechanism for Heme-Mediated Inhibition of 5-Aminolevulinic Acid Synthase 1

Autor:	Koichiro Ishimori, Shigetoshi Aono, Mariko Ogura, Chihiro Kitatsuji, Takeshi Uchida
Rok vydání:	2014
Předmět:	Cell type ATP synthase biology General Chemistry Mitochondrion Isozyme ALAS1 chemistry.chemical_compound Biochemistry chemistry biology.protein Molecular mechanism 5-Aminolevulinic Acid Synthase 1 Heme
Zdroj:	Bulletin of the Chemical Society of Japan. 87:997-1004
ISSN:	1348-0634 0009-2673
DOI:	10.1246/bcsj.20140111
Popis:	Mammalian 5-aminolevulinic acid synthase 1 (ALAS1), an isozyme expressed in all cell types, catalyzes the first reaction in the heme biosynthetic pathway in mitochondria. Heme regulates ALAS1 funct...
Databáze:	OpenAIRE
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