Intrathekale Interferontherapie einer chronischen Echovirusmeningoenzephalitis bei Agammaglobulinämie vom Typ Bruton

Autor:	B Herrmann, H Wehinger, R Deppermann, A von der Wense, F Harms
Rok vydání:	1998
Předmět:	Echovirus medicine.diagnostic_test biology business.industry Lumbar puncture Meningoencephalitis medicine.disease_cause medicine.disease Virus Immunopathology Pediatrics Perinatology and Child Health Immunology medicine biology.protein Enterovirus Viral disease Antibody business
Zdroj:	Klinische Pädiatrie. 210:51-55
ISSN:	1439-3824 0300-8630
Popis:	A 9-year-old body with X-linked agammaglobulinemia developed chronic enteroviral meningoencephalitis (CEMA) caused by echovirus type 6. Intravenous treatment with selected immunoglobulin charges containing high titers against echovirus type 6 or combination with beta-interferon did not result in improvement. After implantation of a Rickham reservoir and periodical administration of intraventricular and intravenous immunoglobulin the virus recurred rapidly each time treatment was stopped. After 20 months of treatment the patient received a combined therapy with beta-interferon and selected immunoglobulin. Both drugs were given by lumbar puncture, intravenously and via Rickham reservoir. Subsequently echovirus type 6 could not be isolated in culture or PCR. Cerebrospinal fluid pleocytosis disappeared. The remission is lasting for more than three years. Intrathecal and intraventricular beta-interferon therapy for CEMA is being reported for the first time. Facing the unfavourable prognosis of the disease this mode of treatment is a new therapeutic approach following failure of other therapies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::efc263700cd4608b26e5a0d0b7b18479 https://doi.org/10.1055/s-2008-1043849 Zobrazit plný text záznamu