Type II hypersensitivity and trimethoprim-sulfamethoxazole
| Autor: | Shelby Allen, Sean Ervin |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class business.industry Sulfamethoxazole Antibiotics medicine.disease_cause medicine.disease Trimethoprim Methicillin-resistant Staphylococcus aureus Dermatology Pancytopenia Hypersensitivity reaction Immunology medicine business Complication Adverse drug reaction medicine.drug |
| Zdroj: | Pediatric Review: International Journal of Pediatric Research. 3:199-201 |
| ISSN: | 2349-3267 2349-5499 |
| Popis: | Trimethoprim-sulfamethoxazole (Septra) is a widely used antibiotic world-wide.The clinical use has been increasing in the pediatric population[1]. Septra has been associated with a broad array of drug associated reactions including gastrointestinal complaints, cutaneous reactions including Stevens-Johnson syndrome and toxic epidermal necrolysisand cytopenias including immune mediated thrombocytopenia[2]. Adverse reactions occur in 6-8% of patients. In the pediatric patient hospitalized for an adverse drug reaction priorexposure to Septra is found in 75% of patients [3].In the case presented we describe a cutaneous reaction to Septra clinically consistent with a Type2 hypersensitivity reaction with associated pancytopenia. Idiosyncratic reactions such as Type 2 hypersensitivity have rarely been reported with Septra exposure.These adverse drug reactions have infrequently been reported to be fatal [4].With the increasing use of Septra for the management of community acquired methicillin resistant Staphylococcus aureus of skin and soft tissue infections [5] clinicians will need to recognize this clinical complication. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|