iRGD decorated liposomes: A novel actively penetrating topical ocular drug delivery strategy
| Autor: | Hai Huang, Xiangrong Song, Xiaorong Yang, Huili Li, Jun Zeng, James Trevor Oswald, Xingchen Peng, Hansi Lu, Yongmei Liu, Ji-Yan Liu, Chaohui Jin |
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| Rok vydání: | 2020 |
| Předmět: |
Liposome
genetic structures business.industry Cancer therapy Drug administration 02 engineering and technology Pharmacology 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences eye diseases Atomic and Molecular Physics and Optics 0104 chemical sciences Corneal permeability Bioavailability Drug delivery Medicine General Materials Science sense organs Electrical and Electronic Engineering 0210 nano-technology business Retention time Ocular bioavailability |
| Zdroj: | Nano Research. 13:3105-3109 |
| ISSN: | 1998-0000 1998-0124 |
| DOI: | 10.1007/s12274-020-2980-9 |
| Popis: | Ocular drug delivery remains a significant challenge that is limited by poor corneal retention and permeation, resulting in low ocular bioavailability (< 5%). Worse still, the most convenient and safe route of ocular drug administration, topical administration results in a drug bioavailability of less than 1%. iRGD modified drug delivery strategies have been developed for cancer therapy, however active targeting iRGD platforms for ocular drug delivery have yet to be explored. Herein, an iRGD modified liposomes was developed for ocular drug delivery via topical administration. The results indicated that iRGD modified liposomes could prolong the corneal retention time and enhance corneal permeability in an iRGD receptor mediated manner. These findings provided a novel strategy for topical ocular drug delivery for the treatment of posterior ocular diseases. |
| Databáze: | OpenAIRE |
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