ChemInform Abstract: Synthesis of 2-(2,6-Dichloro-4-pyridyl)-3-propargyl-5-ethyl-6-methyl-4( 3H)-pyrimidinone, a Promising New Herbicide

Autor:	Zev Lidert, Edward C. Taylor, Ping Zhou, Renee Caroline Roemmele, Colin M. Tice
Rok vydání:	2010
Předmět:	chemistry.chemical_compound Decarboxylation Chemistry Propargyl Aromatization Regioselectivity Sulfoxide General Medicine Sigmatropic reaction Medicinal chemistry Isomerization Demethylation
Zdroj:	ChemInform. 28
ISSN:	0931-7597
DOI:	10.1002/chin.199738194
Popis:	A novel synthesis of the promising new herbicide 2-(2,6-dichloro-4-pyridyl)-3-propargyl-5-ethyl-6-methyl-4(3 H )-pyrimidinone (12) is reported which features (1) regioselective carbon, followed by nitrogen, dialkylation of an intermediate dianion, and (2) a tandem “one-pot” sequence of reactions involving sigmatropic sulfoxide elimination, lithium chloride-induced demethylation of a carbomethoxy grouping, decarboxylation, and isomerization/aromatization.
Databáze:	OpenAIRE
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