Impact of prednisone on TGF-?1 and collagen in diaphragm muscle frommdx mice
| Autor: | Cathy M. Pollina, Granchelli Ja, Luc E. Gosselin, Michael S. Hudecki, James V. Hartel |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Physiology business.industry medicine.drug_class Ratón Duchenne muscular dystrophy Inflammation musculoskeletal system medicine.disease Diaphragm (structural system) Cellular and Molecular Neuroscience Hydroxyproline chemistry.chemical_compound Endocrinology chemistry Prednisone Physiology (medical) Internal medicine Medicine Corticosteroid Neurology (clinical) Muscular dystrophy medicine.symptom business medicine.drug |
| Zdroj: | Muscle & Nerve. 24:428-432 |
| ISSN: | 1097-4598 0148-639X |
| DOI: | 10.1002/1097-4598(200103)24:3<428::aid-mus1018>3.0.co;2-e |
| Popis: | The purpose of this study was to assess the impact of prednisone treatment for 8 weeks on the level of transforming growth factor-beta 1 (TGF-beta1), hydroxyproline (HYP) concentrations, and level of the mature, nonreducible collagen cross-link hydroxylysylpyridinoline (HP) in diaphragm muscle from 12-week-old mdx mice. Diaphragm muscle from untreated mdx mice had a significantly higher level of TGF-beta1, HYP, and HP cross-link compared with normal C57BL/10J (control) mice. Prednisone treatment significantly reduced the level of TGF-beta1 and HYP in diaphragm from mdx mice to values similar to control mice, but resulted in a higher level of the HP cross-link compared with untreated mdx mice. These findings indicate that short-term treatment of mdx mice with prednisone can attenuate the fibrotic response in diaphragm muscle, possibly by mediating the level of TGF-beta. Although prednisone was beneficial in preventing collagen accumulation, it resulted in a higher level of the HP cross-link, presumably by decreasing collagen turnover |
| Databáze: | OpenAIRE |
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