Synthesis, Antitumor Activity and Crystallographic Studies of Analogues of Tiazofurin

Autor: Loredana Cappellacci, Mario Grifantini, Barry M. Goldstein, R. Moraca, Giuseppe Nocentini, G. Abu Sheikha, Palmarisa Franchetti, L. Messini
Rok vydání: 1995
Předmět:
Zdroj: Nucleosides, Nucleotides and Nucleic Acids. 14:637-640
ISSN: 1525-7770
DOI: 10.1080/15257779508012440
Popis: The syntheses and antitumor activity of 2-β-D-ribofuranosylfuran-4-carboxamide (furanfurin) and 2-β-D-ribofuranosylthiophene-4-carboxamide (thiophenfurin) are reported. The X-ray structure of ethyl 2-β-D-ribofuranosylthiophene-4-carboxylate, precursor of thiophenfurin, is also presented. Only thiophenfurin showed activity as an antitumor agent both in vitro and in vivo.
Databáze: OpenAIRE